Inherited epigenetic variation--revisiting soft inheritance
by
Richards EJ.
Department of Biology, Washington University,
1 Brookings Drive, St Louis,
Missouri 63130, USA.
richards@biology2.wustl.edu
Nat Rev Genet. 2006 May;7(5):395-401.

ABSTRACT

Phenotypic variation is traditionally parsed into components that are directed by genetic and environmental variation. The line between these two components is blurred by inherited epigenetic variation, which is potentially sensitive to environmental inputs. Chromatin and DNA methylation-based mechanisms mediate a semi-independent epigenetic inheritance system at the interface between genetic control and the environment. Should the existence of inherited epigenetic variation alter our thinking about evolutionary change?

Private eugenics
Personal genomics
Psychiatric genetics
Germline epimutation
Human self-domestication
Selecting potential children
Brain size/human evolution
Transhumanism/Brave New World?
Transgenerational epigenetic effects
Transgenerational epigenetic inheritance
Developmental and environmental variation in genomes
Maternal inheritance, epigenetics and the evolution of polyandry

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