Susceptibility to breast cancer:
hereditary syndromes and low penetrance genes
by
Nusbaum R, Vogel KJ, Ready K.
Georgetown University,
Lombardi Comprehensive Cancer Center,
Washington, DC 20007-2401, USA.
rhm23@georgetown.edu
Breast Dis. 2006-2007;27:21-50.

ABSTRACT

Several genes are associated with hereditary susceptibility to breast cancer. Most notably these include BRCA1 and BRCA2; however, other less common gene mutations which confer elevated breast cancer risk are associated with Cowden syndrome, Li-Fraumeni syndrome, Peutz-Jeghers syndrome, ataxia-telangiectasia heterozygosity and hereditary diffuse gastric cancer. In this article we highlight the genetic epidemiology, gene function, genotype-phenotype correlations, cancer risks and clinicopathologic findings for the cancer susceptibility genes related to these syndromes. We also examine genes, such as CHEK2, which confer a lower penetrance for breast cancer in comparison to these highly penetrant genes.

Biohappiness
Genospirituality
Cognitive genetics
Personal genomics
Human self-domestication
Germline genetic engineering
Preimplantation genetic diagnosis
A life without pain? Hedonists take note'
'The Principle of Procreative Beneficience'
Francis Galton and contemporary eugenics
Do the DREAMless learn more and age less?
Gene therapy and performance enhancement
Institute for Germinal Choice ('Genius Sperm Bank')

Refs
and further reading

HOME
Resources
Wireheading
BLTC Research
nootropic.com
Superhappiness?
Utopian Surgery?
The Good Drug Guide
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
MDMA: Utopian Pharmacology
Critique of Huxley's Brave New World